(6S)-5-methyltetrahydrofolate (ACTIVE FOLATE)
Quatrefolic® is water soluble. Several several pre-clinical and clinical studies have evaluated and assessed the improved bioavailability of Quatrefolic® in comparison to the (6S)-5-methyltetrahydrofolate calcium salt. Several protocols have been carried out both on animal and human models.
The first test was a direct comparison between Quatrefolic®, (6S)-5-methyltetrahydrofolate calcium salt and folic acid in rats that has allowed to know the difference of bioavailability in-vivo between the three folate generations.
Once the animal studies were completed, a human clinical trial was performed, confirming Quatrefolic® owns a superior bioavailability profile over the (6S)-5-methyltetrahydrofolate calcium salt. It was a single dose, balanced, two sequences, two periods, two treatments ramdomized crossover study.
Improved Bio availability:
*Quatrefolic® is a registered trademark of Gnosis, SpA. Patent # 7,947,662 CAS# 1181972-37-1 .