HerbDoc

About our Herbathione Herbal Tincture and the Herbs we Use
in our Spectrum Support Formulas

by Michael Lang

Glutathione is one of the body's most powerful natural antioxidants and is a sulfur-
rich tripeptide bonded from the three amino acids Cysteine, Glutamine, and Glycine.
One of it's most crucial functions is as Glutathione Peroxidase, which protects our
body's cellular membranes from damage due to lipid peroxidation from hydrogen
peroxide and other free radical challenges. Glutathione detoxifies many chemicals,
including phenols, bacterial toxins, household chemicals, pesticides, and heavy metals.1

Exposure to environmental toxins and genetically-acquired defects in sulfur
metabolism, or "envirogenetic" compromises in glutathione synthesis may hinder our
body's ability to detoxify the toxins we encounter in our environments.2 The
absorption of orally administered glutathione can be limited and even IV
administration can have limited duration of elevated plasma levels.3 Vitamin C, Alpha
Lipoic Acid, along with other antioxidant vitamins and minerals facilitate enhanced
synthesis and recycling of glutathione which may serve to raise its plasma levels.4,5,6,7

HerbaThione, our herbal tincture, was carefully formulated to provide botanical
antioxidant support of glutathione synthesis and recycling, as well as antioxidant,
detoxification, immune, gastro-intestinal, & neurological function support. BrainChild
Nutritionals is pleased to introduce this organically grown alcohol-free proprietary
herbal extract blend to its line of quality liquid nutritional supplements. HerbaThione
is an herbal tincture that combines the best of Western, Chinese, and Ayurvedic herbal
traditions utilizing the following herbal antioxidant and liver protective constituents:

Ashwaganda Root

(Withania somnifera)

Known as "Ayurvedic Ginseng", Ashwaganda has been used for centuries as a nervous
system rejuvenator/protectant, for immune support, and for support of sleep
disturbances, wasting diseases, failure to thrive in children, joint and nerve pains. It
supports detoxification via its antioxidant function in the recycling of glutathione and
support of superoxide dismutase.8,9,10,11

Burdock Root

(Arcticum lappa)

A mucilaginous herb that reduces inflammation and controls bacterial infection. Mild
laxative. Supports lung, kidney, spleen, pituitary, lymphatic, thymus, and immune
health. Blood cleanser and purifier, used with inflammatory conditions of chronic
toxicity and for skin conditions. Promotes bile flow, liver cleansing, and enhanced liver
glutathione. 12,13

Chinese Astragalus Root

(Astragalus membranaceus)

A nourishing tonic that stimulates the immune system, spleen, lungs, adrenals, liver,
circulatory, lymphatic, and urinary systems, lowers blood pressure and blood sugar
levels. Aids digestion, promotes healing, inhibits lipid peroxidation. 14,15,16

Fennel Seed

(Agastache foeniculum)

A sweet aromatic flavoring herb that also promotes gastrointestinal motility, the
functions of the liver, kidneys, spleen and supports respiratory function. Relieves
abdominal pain, colon disorders, gas, and gastrointestinal tract spasms. Also, a natural
sulfur source. 17,18,19

Ginkgo Biloba Leaf

(Gingko Biloba)

Powerful antioxidant, dilates bronchial tubes and blood vessels, specifically increases
cerebral and cardiac blood flow and available cerebral oxygen, controls allergic
responses, and improves cardio-pulmonary function. Has anti-fungal and antibacterial
effects. Helpful for depression, Used for asthma, allergic inflammatory responses,
cerebral insufficiency. Inhibits allergic response. Improves digestion. Increases cellular
glutathione and liver-specific glutathione S-transferase.20,21.

Gotu Kola Leaf

(Centella asiatica)

Improves circulatory problems in the extremities and speeds healing. A rejuvenating
herb that helps in wound healing, ulcerative conditions, depression and other nervous
disorders. Improves muscle tone. and improves cardio-pulmonary function.
normalizes blood pH. Supports liver and adrenal function. Known in Sanskrit as
brahmi, meaning "bringing knowledge," and used to instill a sense of well being prior to
meditation. This historical usage may be attributed to its effects on boosting
acetylcholine. A potent antioxidant, it can raise levels of glutathione and antioxidant
enzymes including catalase, glutathione peroxidase and superoxide dismutase.22,23.

Gymnema Sylvestre Leaf

(Gurmar)

Lowers blood sugar levels and helps to curb cravings for sweets by diminishing the
taste bud to brain "sweet taste" response to sugar and supportive for normalizing blood
sugar. Used in India as a daily garnish with meals. It also has been shown to increase
fecal excretion of steroids and bile and inhibits mast cell release of histamine and
hyaluronidase in allergic reactions.24,25,26,27

Milk Thistle Seed

(Silibum marinum)

Protests the liver against toxins, particularly lipid peroxidation. Herbal
antioxidant/free radical quencher. Leukotriene inhibitor. Regenerates liver cells and
stimulates bile flow. Relaxes spasms. Sulfur source. Assists in regeneration of
glutathione and restoration of cellular thiol status. Kidney support. Adrenal support.
Aids inflammatory bowel disorders, weakened immune function. Helps to detoxify
alcohol, drugs, and other chemical toxins.28,29,30.

Chinese Sarsaparilla

(Smilax Glabra)

A cooling, alterative herb that has antibiotic, anti-inflammatory, diuretic Used to clear
toxins, particularly mercury and other heavy metals, and for liver, joint, skin, and
urinary tract support, and skin. Enhances activities of antioxidant enzymes catalase,
superoxide dismutase, and glutathione peroxidase.29,30.

Schisandra Fruit

(Schisandra chinensis)

Regulates secretion of body fluids, moistens dry and irritated tissues. Acts as a tonic for
the nervous, urinary, and cardiac systems. Liver protectant. Used traditionally for
asthma, night sweats, urinary disorders, chronic and early morning diarrhea,
palpitations, insomnia, poor memory. Supports detoxification via recycling of
glutathione.

Beet-derived hypoallergenic ascorbic acid

(Vitamin C)

Vitamin C facilitates enhanced synthesis and recycling of glutathione more effectively
than either oral glutathione or N-Acetyl Cysteine.4,5,6,7

L-Glycine

This amino acid is 1/3 of the tripeptide construct of glutathione, along with cysteine and
glutamine. Glycine also functions as a the driving force for the singular glycine-driven
phase II chemical detoxification pathway. This pathway clears phenols, salicylates,
benzoates, excess organic acids, and many other toxins from the body. It is utilized in
the construction of DNA and RNA, the synthesis of bile acids, in the repairing of
damaged tissues, and is crucial in nervous system function as an inhibitory
neurotransmitter.31,32, 33,34.

Natural Lemon flavor

(Citrus limon)

Improves digestion, lowers blood pressure, diuretic, reduces inflammation, promotes
gluconoride detoxifcation, improves peripheral circulation, and controls bacterial and
fungal infections. Used for indigestion, flatulence, diarrhea, infant colic, and shock.

Coconut glycerine

Inhibits cellular adhesion of bacteria and fungi, contains broad trace mineral profile.
Provides sweetening and gentle laxative properties.

Herbathione is a proprietary formulary of herbs in a base of glycerine, distilled water
and natural lemon flavor. This tincture is free of alcohol, gluten, casein, soy, corn, sugar,
artificial colors, flavors, sweeteners, or preservatives. Shake well before each use and
refrigerate after opening,

Herbathione Dosage: 2 full droppers under the tongue, 2-3 times a day 30 minutes before
meals. Use 1 dropper 2x per day for children under five. Do not use with a cold/flu or
during pregnancy or breast feeding, prior to surgical procedures, or concurrently with
blood-thinning medications. Consult with a qualified health practitioner prior to use if
you have pre-existing health conditions.

Citation References:

1.Patrick L.. Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha
lipoic acid In the treatment of mercury toxicity. Alternative Medical Review. 2002
Dec;7(6):456-71.

2. Sandir, R, Gill KD. Effect of lead on lipid peroxidation in liver of rats. Biological Trace
Element Research. 1995 Apr;48(1):91-7.

3.Witschi A. The systemic availablilty of oral glutathione. European Journal of Clinical
Pharmacology 1992 43 667-69

4. Meister A. On the antioxidant effects of ascorbic acid and glutathione. Biochemical
Pharmacology. 1992; 44:1905-15.

5Johnston CJ, Meyer CG, Srikakshimi JC. Vitamin C elevates red blood cell glutathione in
healthy adults. American Journal of Clinical Nutrition. 58 103-5 1993

6.Jain A, et al.,, Effect of ascorbate or N-acetylcysteine treatment in a patient with
hereditary glutathione synthesase deficiency. Jouranl of Pediatrics 124 229-33 1994.

7.Das KK, Das Sn, DasGupta S. The influence of ascorbic acid on nickel-induced hepatic
lipid peroxidation In rats. Journal of Basic Clinical Physiollogy and Pharmacology
2001;12(3):187-95

8.Jain S, Shukla SD, Sharma K, Bhatnagar . Neuroprotective effects of Withania
Somnifera Dunn. In hippocampal sub-regions of female albino rat. Phytotherapy
Research 2001 Sep;15(6):544-8.

9.Davis L, Kuttan G, Immunomodulatory activity of Withania Somnifera. Journal of
Ethnopharmacology 2000 Jul;71(1-2):193-200.

10.Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides
from Withania Somnifera. Indian Journal of Experimental Biology 1997 Mar;35(3)236-9.

11.Chaurasia SS, Panda S, Kar A. Withania Somnifera root extract in the regulation of
lead-induced oxidative damage in the male mouse. Pharmacological Research 2000
Jun;41(6):663-6.

12.Lin SC, Chung TC, Linn CC, Ueng TH, Lin YH, Lin SY, Wang LY. Hepatoprotective
effects of Arcticum Lappa on Carbon Tetrachloride and acetominophen-induced liver
damage. Am Journal of Chinese Medicine 2000;28(2):163-73.

13. .Lin SC, Lin CH, Lin CC, Lin YH, Chen CF, Chen JC, Wang, LY. Hepatoprotective
effects of Arcticum Lappa on liver injuries induced by chronic ethanol consumption &
potentiated by carbon tetrachloride. Journal of Biomedical Science. 2002 Sep-Oct;9
(5):401-9.

14.Zhao KS; Mancini C; Doria G. Enhancement of the immune response in mice be
Astragalus Membranaceus extracts. Immunopharmacology 1990 Nov-Dec;20(3):225-
33.

15.Zhang, ZL; Wen QZ; Liu CX. Hepatoprotective effects of Astragalus root. Journal of
Ethnopharmacology 1990 Sep;30(2):145-9.

16.Toda S, Yase Y,Shirataki Y, Inhibitory effects of of Astragali Radix on lipid
peroxidation and protein oxidative modification of mouse brain homogenate by copper.
Phytotherapy Research 2000 Jun;(4):294-6.

17.Alexandrovich I, Rakovitskaya O, Kolmo E, Sidorova T, Shushunov I. The effect of
fennel (Foeniculum Vulgare) seed oil emulsion In Infantile colic: a randomized, placebo-
controlled study. Alternative Therapies In Health and Medicine 2003 Jul-Aug;(4):58-61.

18.Toda S. Inhibitory effects of aromatic herbs on lipid peroxidation and protein
modification by copper Phytotherapy Research May;17(5)546-8.

19.Ozbeck H, Ugras S Dulger H, Bayram I, Tuncer I, Ozturk G, Ozturk. Hepatoprotective
effect of Foeniculum vulgare essential oil. Fitoterapia 2003 Apr;74(3)317-9.

20Rimbach G, Gohil K, Matsugo S, Moini H, Saliou C, Virgili F, Weber SU, Packer L.
Induction of glutathone synthesis In human keratinocytes by Gingko Biloba extract.
Biofactors. 2001;15(1):39-52.

21Sasaki K, Hatta S, Wada K, Ueda N, Yoshimura T, Endo T, Sakata M, Tanaka T, Haga
M. Effects of extract of Gingko Biloba leaves and Its constituents on carcinogen-
metabolizing enzyme activites and glutathione levels In mouse liver. Life Science. 2002
Feb 22;70(14):1657-67

22. Shukla A, Rasik AM, Dhawan BN. Asiaticoside-Induced elevation of antioxidant
levels in healing wounds.Phytotherapy Research 1999 Feb;13(1):50-4.

23.Jayashee G, Kurup, Muraleedhara G, Sudarslal S, Jacob VB. Anti-oxidant activity of
Centella Asiatica on lymphoma-bearing mice. Fitoterapia 2003 Jul;74(5):431-4.

24Harada S, Kasahara Y. Inhibitory effect of gurmarin on palatal taste responses to
amino acids in the rat. Department of Oral 25Physiology, Kagoshima University Dental
School, 8-35-1

25Sugihara Y, Nojima H, Matsuda H, Murakami T, Yoshikawa M, Kimura I.
Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema
Sylvestre leaves in streptozotocin-diabetic mice. Journal of Asian Natural Product
Research. 2000;2(4):321-7.

26Nakamura Y,Tsumura Y, Tonogi Y, ShibataT. Fecal steroid excretion is increased in
rats by oral administration of gymnemic acids contained in Gymnema Sylvestre leaves.

27Sawabe Y, Nakagomi K, Iwagami S, Suzuki S, Nakawaza H. Inhibitory efects of pectic
substances on activated hyaluronidase and histamine release from mast cells.
Biochemical Biophys Acta. 1992 Nov 17;1137(3):274-8.

28.Valenzuela A, Aspillaga M, Vial S, Guerra, Selectivity of silymarin on the increase of
the glutathione content in different tissues of the rat. Planta Medica 1989 Oct;55(5):420-
2.

29.Muriel P, Garciapina T, Perez-Alvarez V, Mourelle M. Silymarin protects against
paracetomol-induced (acetominophen) lipid peroxidation and liver damage. Journal of
Applied Toxicology. 1992 Dec;12(6):439-42.

30.Tager M, Dietzmann J, Thiel U, Hinrich, Neumann K, Ansorge S. Restoration of the
cellular thiol status of peritoneal macrophages from CAPD patients by the flavinoids
silibinin and silymarin. Free Radical Research. 2001 Feb;34(2):137-51.

29.Lee S, Ju E, Kim J. Free radical scavenging and antioxidant enzyme fortifying
activities of extracts from Smilax China root. Experimental and Molecular Medicine.
2001 Dec;33(4):263-8.

30.Tripathi YB, Upadhyay AK, Chaturvedi P. Antioxidant property of Smilex China
Linn. Indian Journal of Experimental Biology. 2001 Nov;39(11):1176-9.

Levy G. Pharmacokinetics of salicylate elimination in man. Journal of Pharmaceutical
Science 1965; 232(3):864-72.

31.Patel DK, Ogunbuna A, Notarini, Bennet PN. Depletion of plasma glycine and effect of
glycine by mouth on salicylate metabolism during aspirin 32..Timbrell JA Principles of
biochemical toxicology. 2nd ed. London: Taylor and Francis, 1991

33.Mulder GJ, editor. Conjugation reactions in drug metabolism: an integrated
approach. London: Taylor and Francis, 1990.

overdose. Human Expermental Toxicology 1990;9:389-95.

34.Kimback G, Inal M, Baycu C. Ethanol-induced hepatotoxicity and protective effect of
betaine (Trimethylglycine). Cellular Biochemical Function 2001 Dec;19(4):281-5.